Abstract

A REVIEW ON ANTIUROLITHIATIC ACTIVITY OF SOME HERBAL DRUGS

Gondkar Shraddha* and Shinde Shraddha

Abstract

A wide range of plants and plants-derived products are used in folk medicine for treatment of urolithiasis as a prophylactic agent or as curative agent. Most of them found to be effective, but still the complete mechanism of action of these herbal drugs remain to be unclear. In present review we are discussing the various mechanism of action through which phytotheraeupatic agents exert their antiurolithiatic effect. Currently known herbal drugs exert their antiurolithiatic properties by altering the ionic composition of urin viz.; Some medicinal plant contain chemical compounds like Glycosaminoglycans (GAGs) which themselves possess an inhibitory effect in the crystallization of calcium oxalate. Antioxidant, constituents of the plant also help in ameliorating the calcium oxalate induced renal cell injury. Thus, antiurolithiatic activity of plants or herbal formulation may be deu to synergism of their diuretic activity, crystallization inhibition along with antioxidant activity.

Keywords: Renal stone, urolithiasis, herbal drug, calcium oxalate stone, magnesium ammonium phosphate stone.