Abstract

“DESIGN, DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERES OF FUROSEMIDE BY MIXED SOLVENCY CONCEPT”

Shubhi Choubey*, Arun Patel, Shailendra Patel and Neelesh Dwivedi

Abstract

To achieve and maintain the drug concentration in the body within the therapeutic range required for a medication, it is often necessary to take conventional drug delivery system several times a day. A number of advancements have been made recently in the development of new techniques for drug delivery. These techniques are capable of regulating the rate of drug delivery, sustaining the duration of therapeutic action, and/or targeting the delivery of drug to a specific tissue. Gastro retentive systems also called as floating systems or hydrodynamically controlled systems are low-density systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm. They are made of polymeric, waxy, or other protective materials, that is, biodegradable synthetic polymers and modified natural products such as starches, gums, proteins, fats and waxes. The natural polymers include albumin and gelatin; the synthetic polymers include polylactic acid and polyglycolic acid.

Keywords: Furosemide, floating microspheres, porogen,