Abstract

ACUTE AND SUB-CHRONIC TOXICITY STUDY OF CORIARIA MYRTIFOLIA LEAVES EXTRACT IN RODENTS

M. Boudkhili*, H. Greche , M.Ait el Cadi , B.Meddah , A.Zellou, A.Bounihi andL. Aarab

Abstract

Coriaria myrtifolia belongs to the Coriariacae’s family. It has the largest fruits in the genus Coriaria. It is an Herbal plant commonly used in western Mediterranean area. In the present study, we investigated the acute and sub-chronic toxicity of the crude methanolic extract of leaves of Coriaria myrtifolia. For acute toxicity, a single oral administration was performed at a dose of 2000 mg/kg body weight in Swice mice. The study of sub-chronic toxicity was evaluated by daily oral administration with the extract at dose 200 mg/kg to Wistar rats for sixty days. No mortality or signs of toxicity were observed in the acute study. Wistar rats were analyzed for body weight, blood chemical. The results showed no toxicity and mortality in either sex comparing to the control group. After sixty days, the extract of Coriaria myrtifolia did produced the increase of neutrophils and decrease of lymphocytes. The extracts of the leaves of Coriaria myrtifolia showed a low toxicity. They are good candidates for further pharmacological investigations.

Keywords: Coriaria myrtifolia, acute toxicity, Sub-chronic toxicity.