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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

APPROACH TO ENHANCE THE SOLUBILITY OF CARVEDILOL USING Î²-CD COMPLEXATION

Dr. S. Chandra*, S. Sangeetha*, S. Kavibharathi, B. Nandhini, R. Suresh and C. Sanjeevkumar

Abstract

The poor dissolution of relatively insoluble drugs has a major pharmacokinetic problem in the oral dosage form. This limits aspects such as absorption and bioavailability. Therefore, several approaches have been followed in improving the solubility of drugs, on being complexation. Carvedilol in HPMC in water and Tween 80 in water formulates as wet and direct compression method (F1-F4) and prepared by kneading method and physical mixture evaluated and characterized by IR, XRD and DSC studies 1:3 complex exhibit higher dissolution rate in direct compression method Cyclodextrin complexation (β-CD) enhanced the absorption rate of carvedilol.

Keywords: Carvedilol, HPMC, Tween 80, Cyclodextrin complexation (?-CD).

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