Abstract

HOLLOW MICROSPHERE AS A DRUG CARRIER: - A REVIEW OF CLASSIFICATION AND PREPARATION TECHNIQUE WITH THEIR APPLICATION

Tomer Kajal*, Gupta Dilip and Khatak Sunil

Abstract

The aim of writing this review on microballoons is to pile up the contemporary literature with a main focus on the novel technological advancements in the floating drug delivery system to achieve gastric retention. Microballoons (Hollow microsphere) assurance to be a potential approach for gastric retention. Microballoons drug-delivery systems are the concept of non-effervescent system accommodating unoccupied particles of spherical shape without core, preferably having a size less than 200 micrometre. the drugs having site-specific absorption for those microballon drug delivery system proven a better significance in controlling the release rate. The floating microballoons presented gastroretentive controlled release delivery of enhancing the bioavailability and promises to be a possible approach for gastric retention. Optimized hollow microspheres will locate the central place in novel drug delivery, especially in safe, targeted, and effective in vivo delivery conveyance to be a possible methodology for gastric retention. They are gastroretentive drug-delivery systems, which give controlled discharge properties. This review focus on limitations, methods used for preparation of hollow microsphere, applications of the hollow microsphere, polymers utilized in hollow microspheres, characterizations of microballoons, and formulation with different assessment and marketed products are covered in detail.

Keywords: Microballoons, Gastroretentive, Buoyancy, absorption, Floating drug delivery system (FDDS) gstric residence time.