Abstract

FORMULATION AND EVALUVATION OF AMLODIPINE BESYLATE SOLID DISPERSION

S. Chandra*, R. Suresh*, S. Kavibharathi, S. Sangeetha, A. Sheikalisha and Hemalatha K.

Abstract

Amlodipine besylate is a drug that is used for treating high blood pressure, certain types of angina and coronary heart failure. One of the major problem with this drug is its low solubility in biological fluids, which result into poor bioavailability after oral administration. The purpose of the presenting investigation was to increase the solubility and dissolution rate of Amlodipine besylate by the preparation of its solid dispersion with polyethylene glycol 6000 and hydroxyl Propyl methyl cellulose (HPMC) by using solvent evaporation method and physical mixture method in the 1:1, 1:2 and 1:3 ratio of the drug and carrier respectively. The prepared solid dispersion were characterized by FT-IR Spectroscopy no interaction of drug with carriers. The solid dispersion were evaluated for percentage practical yield, drug content and invitro dissolution study. The formulation code F3 of Amlodipine besylate solid dispersion prepared by solvent evaporation method using polyethylene glycol 6000 at 1:3 ratio drug and carrier is highest improvement in the dissolution profile, at the end of 60 minutes, formulation F3 gave the highest drug release that is 89.50%.

Keywords: Solid dispersion, Amlodipine besylate, Hydroxypropyl methy cellulose, polyethylene glycol 6000, acetone and hydrochloric acid.