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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

POLYHERBAL EXTRACTS FROM GONGRONEMA LATIFOLIUM AND OCIMUM GRATISSIMUM IMPAIRED LIVER FUNCTION IN ALLOXAN INDUCED DIABETIC RATS

*Agbai Emmanuel Onuka

Abstract

The effect of four weeks co-administration of gongronema latifolium and ocimum gratissimum was studied in alloxan induced diabetic rats. At the end of the period of extract administration, results showed that extracts caused a slight decrease in blood glucose, alkaline phosphatase, total bilirubin and albumin levels, although not significant compared to normal control (P > 0.05), but caused an elevated AST and ALT levels (P < 0.05). Data suggest that coadministration of these extracts may be harmful to the liver.

Keywords: gongronema latifolium. ocimum gratissimum. hepatic enzymes. bilirubin. albumin. Alloxan.

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