Abstract

PREFORMULATION STUDIES OF DEXAMETHASONE LOADED NIOSOMAL GEL

Aarti Hardia*, Amisha Mahajan, Aashish Hardia

Abstract

Dexamethasone is a synthetic corticosteroid, used for the suppression of the immune response and inflammation. These are very effective in the treatment of inflammatory conditions. The objective of Preformulation study is to developed stable and bioavailable dosage form. Preformulation parameter use to maximize the chances to get a safe, efficacious and stable product. Administration of conventional dosage form of Dexamethasone exhibit delayed drug release and unwanted side effects so Dexamethasone incorporated into niosomes gel base improve therapeutic performance, improve penetration through skin and improve patient compliance, hence the objective of the study was made to develop sustained release gel containing niosomal vesicles of Dexamethasone using Carbopol 940 as a polymer which controlled the release of drug, decrease dosing frequency of administered drug. Preformulation studies were carried out for identification, solubility, FTIR, compatibility studies. All the observation and results showed that the Dexamethasone serve as suitable candidate for Topical drug delivery system that may improve the Permeability.

Keywords: Niosome, FTIR, Dexamethasone, Stability.