Abstract

COMPARATIVE INHIBITION OF CANCER CELL LINES BY THE SYNTHETIC THYMIDING NUCLEIC ACIDS AND GROUP 4 METALLOCENE DICHLORIDES AND ORGANOTIN DIHALIDES

Jessica Frank, Michael R. Roner, Charles E. Carraher, Jr.*, Kimberly Shahi and Loretta Chen

Abstract

The ability to inhibit cancer cell lines by two groups of synthetic nucleic acids derived from thymidine and group 4 metallocenes and organotin dihalides was evaluated. Overall, the group 4 metallocene synthetic nucleic acids showed superior ability to inhibit the cell lines compared with the organotin dihalides with good inhibit in the nanogram/mL range. Within the group 4 metallocene polymers, the order of inhibition was Zr>Hf>Ti. Thus, for this group of polymers the zirconocene polymers show the greatest ability to inhibit cancer cell lines.

Keywords: thymidine, organotin dihalides, organotin polymers, synthetic nucleic acids, metallocene polymers, pancreatic cancer, breast cancer, glioblastomas brain cancer, interfacial polymerization.