Abstract

SYNTHESIS AND STUDY OF SOME ALKOXYPHENYLACETAMIDE DERIVATIVES AS POTENTIAL MEMORY ENHANCING AGENTS

Nigar Nahid Mansoori, Arun Patel, Shailendra Patel* and Neelesh Kumar Dwivedi

Abstract

Memory enhancement research was primarily focused on neurodegenerative diseases such as Alzheimer‟s disease, because one of the characteristic features of AD is progressive loss of memory. The past two decades have witnessed a considerable research effort directed towards discovering the cause of Alzheimer‟s disease with the ultimate hope of developing safe and effective pharmacological treatments.[64] Current treatments for AD have only moderate symptomatic effects on the disease. The cholinergic hypothesis involved in mechanism of AD has led to development of anticholinesterase drugs such as tacrine, donepezil and rivastigmine. These drugs can slowdown or moderate the effects of the disease, but they do not reverse the progressive degeneration of the brain itself.[65,66] In recent years, much attention has been focused on the design of palliative agents that have the ability to offer subtle cognitive improvement.[67] Since the cholinesterase inhibitors confer only modest benefits, additional non-cholinergic Alzheimer‟s disease therapies are urgently needed. Several non-cholinergic agents are currently under development for the treatment and/or prevention of Alzheimer‟s disease.

Keywords: Alzheimer?s disease, Alkoxyphenylacetamide Derivatives, memory, neuroscience, Dementia, neuronal.