Abstract

AN ANTIOXIDANT LYCOPNE EFFECTIVE IN OSMF- AN INVIVO STUDY

Dr. Deval M. Choukhe, *Dr. Pratik C. Parkarwar, Dr. Talat Mohammadi and Dr. Akash Lavate

Abstract

OSMF is the potentially malignant disorder affecting the oral cavity. It mostly affects the young generation as they are addicted to the tobacco associated products. The basic cause for this disorder is due to consumption of betel nut causing reduce mouth opening, burning sensation and lastly causing fibrosis of mucosa. The subjects show symptoms like marblestone like, blanching and stiffness of oral mucosa, difficulty in swallowing, alter speech and shrunken uvula. This disorder if not prevented may turn into malignancy. The disorder can be treated by stoppage of consumption of betel nut, topical and systemic pharmacological agents, mouth opening exercises and surgery. In the drugs list antioxidant, corticosteroids (topical), turmeric, immused milk, vasodilators are used and found to be effective. The study was done on 30 subjects suffering from Grade I and Grade II stages of OSMF with thirty days interval and prescribed on Lycopene 16 mg per day and placebo for three months. There was reduce in burning sensation and increase in mouth opening of OSMF subjects. The study concluded that Lycopene capsules showed improvement in mouth opening and decrease in the burning sensation in the oral cavity.

Keywords: OSMF, areca nut, blanching, burning, mouth opening, lycopene.