Abstract

PRELIMINARY STUDIES ON ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF SPILANTHES ACMELLA (MURR.)

Mrs. Geetika Sharma*, Maniratna Nareda, Dr. Pushpendra Singh Naruka and Dr. Yuvraj S. Sarangdevot

Abstract

Objective: To evaluate the analgesic and anti-inflammatory activities of the alcoholic extract of stem of Spilanthes acmella in experimental animal models. Material and methods: Spilanthes acmella was evaluated for anti inflammatory action by carrageenan- induced rat paw edema. The analgesic activity was tested by tail flick method in albino rats. Result: The alcoholic extract of Spilanthes acmella at a doses of 200 and 400 mg/kg showed 52% and 60% inhibition of paw edema respectively at the end of three hours and the In the tail flick model, the alcoholic extract of Spilanthes acmella in the above doses increased the pain threshold significantly after 30 min, 1, 2 and 4h of administration. SPA showed dose-dependent action in all the experimental models. Conclusion: The present study indicate that the alcoholic extract showed significant analgesic activity and anti-inflammatory activity at dose 200 mg/kg and 400mg/kg BW.

Keywords: Carrageenan, tail flick, Spilanthes acmella (SPA).