Abstract

DEVELOPMENT AND EVALUATION OF THE ANTIINFLAMMATORY TRIAMCINOLONE ACETONIDE LOADED NIOSOME

*Desai Sanjeevani R. ¹, D’souza John I. ²

Abstract

Niosomes signify an emerging class of novel vesicular systems. Niosomes are self assembled vesicles composed mainly of synthetic surfactants and cholesterol. Niosome are now widely studied as an alternative delivery system to liposome. An increasing number of non ionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic molecules. In our present study we incorporated Triamcinolone Acetonide into niosome by using Ether injection method by applying 32 factorial design. The niosomes were characterized for size distribution, drug entrapment efficiency, zeta potential and drug release profile. Microscopic observation confirmed the uniformity of size and shape and was found to be in the range of 2.52 - 3.42 μm. The entrapment efficiency of the vesicles was determined by ultracentrifugation and was found to be in the range of 69-88%. The stability studies showed that vesicles have greater stability at 40C followed by 250C. From the present investigation, it can be concluded that the developed niosome formulation of Triamcinolone Acetonide has shown great potential in the treatment of inflammation. The results of this study indicate that drug loaded niosomes were able to control the release of Triamcinolone Acetonide and might be of value to extend further into topical formulations.

Keywords: Niosomes, Factorial design, TEM, Entrapment efficiency, Antiinflammatory.