Abstract

CARDIOPROTECTIVE EFFECT OF METHANOL EXTRACT OF JATROPHA TANJORENSIS LEAVES IN ISOPRENALINE INDUCED MYOCARDIAL INFARCTION IN ALBINO RATS: CARDIAC FUNCTION BIOMARKERS, ANTIOXIDANT AND HEART HISTOARCHITECTURE EVALUATION

Enete Uchenna, Ajah Obinna, Unegbu Chika C.* and Nnaoma IKenna E.

Abstract

Background of the Study: Coronary artery disease and its end results, myocardial infarction is a significant cause of morbidity and mortality globally. Recently, there is an increase in the incidence of myocardial infarction which manifest as a result of disrupted blood supply and oxygen to the myocardium. Objective: This present study evaluated the cardioprotective effect of methanol extract of Jatropha tanjorensis leaves on some cardiac functions biomarkers, endogenous antioxidant activity and pathology of the heart in isoprenaline induced myocardial infarction in albino rats. Method: Seventy two albino rats were randomly divided into six (6) groups of Twelve rats per group. Group 1 served as the normal control, group 2 was the negative control (administered 85mg/kg of isoprenaline only), group 3 served as the positive control (pretreated with 2mg/kg carvedilol for 28 days, group 4 through 6 were pretreated with 200mg/kg, 400mg/kg and 600mg/kg the extract respectively for 28 days. Myocardial infarction was induced in the rats using subcutaneous injection of 85mg/kg Isoprenaline (ISO) for two consecutive days (26th and 27th) at 24hours interval. Results: The result of the study showed the extract at the dose of 400mg/kg significantly (p

Keywords: myocardial infarction, isoprenaline, cardiac biomarkers, carvedilol, Jatropha tanjorensis.