Abstract

EFFECT OF THE AQUEOUS EXTRACT OF SESBANIA GRANDIFLORA LINN IN ALLOXAN INDUCED DIABETES IN ALBINO RATS

Radhika J*, Ruth Christia C, Jothi G

Abstract

Diabetes mellitus is the syndrome of disturbed energy homeostatis. It has become a major public health challenge in all over the world. The present study was designed to evaluate the antidiabetic potential of aqueous extract of Sesbania grandiflora Linn. Wistar strain of albino rats were divided into six groups of six rats each. The groups were Group I (Normal control), Group II (Alloxan induced diabetic control (150 mg/ kg.b.wt)), Group III (Alloxan + Sesbania grandiflora Linn (500 mg/ kg.b.wt), Group IV (Alloxan + Sesbania grandiflora Linn (750 mg/ kg/b.wt), Group V (Alloxan + Glibenclamide (200 mg/ kg.b.wt), Group VI (plant treated (750 kg/b.wt)) respectively. After the experimental period of 45 days, the blood and tissue samples were collected and used for analyzing various biochemical and enzymatic parameters such as plasma glucose, serum insulin, glcosylated hemoglobin, hepatic glycogen, glucokinase, glucose-6-phosphatase, serum marker enzymes (AST, ALT and ALP). Group II rats showed significant increase in the level of plasma glucose, glycosylated hemoglobin, glucose-6-phosphatase and serum marker enzymes (AST, ALT and ALP) and decrease in insulin, hepatic glycogen, glucokinase. Oral administration of Sesbania grandiflora Linn aqueous extract to diabetic rats restored all the biochemical parameters and a serum marker enzyme level which depicts the promising antidiabetic effect of Sesbania grandiflora Linn.

Keywords: Sesbania grandiflora Linn, Diabetes, Alloxan, glucokinase, glucose-6-phosphatase.