Abstract

A REVIEW REPORT ON ROLE OF COENZYME Q AS A ENDOGENOUS ANTIOXIDANTS

*Geetika Pant and Harendra Bisht

Abstract

This report gives an overview of a number of functions for antioxidants that have been established from decades. This article particularly focuses on the role of Coenzyme Q10 as an endogenous antioxidant which is of dominating interest. This compound is obtained from natural resources and is self-generated inside the body. The coenzyme Q10 is an endogenously synthesized lipid soluble antioxidant. The effect of coenzyme Q10 is beneficial for health as an endogenous antioxidant but its excess use is detrimental. It causes cancer by free radicals which are produced by oxidation. This report includes a review of the general aspects of endogenous antioxidants systems which will provide a different point of view about antioxidants and explain diseases which are caused by production of free radicals. Also, various actions of coenzyme Q10 have been discussed in respect to various clinical trials that have been performed. Coenzyme Q10 is one of the most significant lipid antioxidants that prevents the generation of free radicals and modifications of proteins, lipids and DNA. The side effects of Coenzyme Q10 may include diarrhea and rashes. Natural resources of coenzyme Q10 are safe for pregnant women.

Keywords: Endogenous antioxidants, ROS, Coenzyme Q 10, Peroxidation, free radicals, oxidative stress.