Abstract

EFFICACY OF AYURVEDIC INTERVENTION OF ANTIINFLAMMATORY ANTI-RHEUMATOID ARTHRITIC (RA) AND ANALGESIA: A COMPREHENSIVE REVIEW

Indrajit Bhattacharya*, Dr. Lalrin Puia, Dr. Sharad D. Pawar, Dr. Amit Kumar Dixit and Dr. P.V.V. Prasad

Abstract

Inflammation not a disease it is a symptoms of our immune system. Due to intervention of any infectious organism our body produced proinflammatory and inflammatory cytokines which leads to inflammatory reaction. The inflammation can be acute of chronic. In both the cases some immunes cells mediates complex of reaction. Any damage in our phospholipid layer activates phospholipid-lipase breaks arachidonic acid (AA), which also synthesized prostaglandin and leukotriene by activation of cyclooxygenase (COX) and lypooxygenase (LOX) enzyme. The Rheumatoid Arthritics (RA) is chronic inflammatory disorder due to over expression of immune system. In RA mainly joints are affected more. Due to activation of Tlymphocyte by antigen dependent activation trigger synovial lining proliferation activation of cytokine production like IL-1, IL-6, IL-8 and Tumor necrosis factor- α (TNF-α). Main pathophysiological hallmark of RA is inflammation in synovium. The proliferation of synovium formed pannus, which migrates to subchondrial bone and cartilage mainly articular cartilage that‘s leads to damage of bone cartilage and tendons. The analgesics are the substances which relives from pain. There are numerous allopathic drugs, NSAIDs are available for anti-inflammatory, anti-rheumatoid arthritis and analgesia but main disadvantages of these drugs is liver damage. The immune‘s suppressant drugs are used for the treatment of RA and main dis-advantages of those drugs leads to other infection. That‘s why these review paper discussed about the Ayurvedic plants which are also effective as anti-inflammatory, anti-rheumatoid arthritis and analgesic

Keywords: COX, IL-1, IL-6, IL-8, pannus, synovium.