Abstract

CURCUMIN AS A NATURAL APPROACH FOR TREATMENT OF ALZHEIMER’S DISEASE

Saurabh Sharma*, Prasanta Kumar Biswal, Varsha Pandey, Ashutosh Kashyap

Abstract

Alzheimer‟s disease a major neurodegenerative disorder that is affecting more that 30 million individuals worldwide. The major pathway associated with this disease are tau phosphorylation, neuroinflammation and oxidative stress. For over a decade many research are been carried out for the early diagnosis and treatment of this neurodegenerative disorder. Curcumin the phytochemical agent present in spice turmeric, have been found to be novel and natural approach in diagnosis and treatment of Alzheimer‟s disease. This review is focused on the activities of curcumin that can prove potential approach in diagnosis and treatment of Alzheimer. Various challenges related to use of curcumin as therapeutic drug and approaches to overcome these challenges. Findings suggest that newer drug therapy associated with curcumin could become a promising therapy for Alzheimer‟s disease.

Keywords: Alzheimer Disease, Neurodegenerative, amyloid plaques, intracellular neurofibrillary tangles, amyloidogenic pathway, lipid peroxidation.