Abstract

BIOENHANCER: AN AGENT FOR INCREASING BIOAVAILABILITY

Prerana Sahu* and Dr. Rajesh Kumar Nema

Abstract

Bioenhancer are an agent which are not medicinal individuals however while they combine with an effective pharmaceutical drug start to the increase of the pharmacologic response of the drug. When every drug molecule are being introduced every year but many of these molecules have problems like their solubility, stability, bioavailability and longlasting side effects. Low bioavailability is one of the serious but treatable problems in the case of the drug molecule. There are also some other circumstances that are obliged for low bioavailability such as low aqueous solubility or effluence by P-gp, etc. These review aims is to discuss the idea of bioavailability to execute a better therapeutic response in suitable dose using natural drugs and natural products like ginger, caraway, aloe, quercetin, glycyrrhizin piperine, curcumin, etc. The use of natural products is for the amount and existent of the drug at which the drug is absorbed improvement because these are harmfree, non-toxic, inexpensive, easily procured, non-addictive, pharmacologically inert and nonallergenic nature, etc. Bioenhancers are utilized for numerous classes of drug-like neutraceuticals, antibiotics, antitubercular and anticancer for instant accouterments. Bioenhancers are also used in several novel drug delivery compositions such as Liposomes, transferosomes, ethosomes, nanoparticles, etc. This review gives the origin of Bioenhancers from natural authorities such as plants and animals with their mechanism and importance in formulation with its future prospective.

Keywords: Bioenhancers, Bioavailability, Piperine, Quercetin.