Abstract

FORMULATION AND EVALUATION OF COLON TARGETTED PULSE IN CAP SYSTEMS OF THEOPHYLLINE FOR NOCTURNAL ASTHMA

Pasam jyothirmayi* B.sivaranjani

Abstract

Asthma may be the most common disease with the largest circadianvariation. Nocturnal asthma is currently controlled by taking either along-acting β2 agonists like salmetrol inhalers, or bronchodilator suchas sustained release Theophylline. The oral route is considered to bemost convenient for the administration of drugs to patients. But it has aserious drawback in conditions where localized delivery of the drug inthe colon is required. The objective of the present study was to developand evaluate an oral pulsatile drug delivery system for asthma byreleasing the drug with a distinct predetermined lag time of 5 hrs toprolong the release and for colon targeting of TPH to treat the nocturnal symptoms of asthma.If the formulation is administered in the night at 10.00 pm symptoms that are experienced inearly morning hours could be avoided. In the present study, polymers such as hydroxylpropyl methyl cellulose and Xanthan gum selected for colon targeting of TPH. TPH granuleswere prepared by wet granulation and polymer plugs were prepared by using polymershydroxyl propyl methyl cellulose and xanthane gum to prolong the release and target to thecolon. These granules filled into the formaldehyde treated capsules and plugged withoptimized polymer plug to maintain the 5hr lag time. Finally capsules are enteric coated withenteric coating polymers and conducted dissolution studies.

Keywords: Asthma, Pulsatile drug delivery system of theophylline, Chrono-biological action, Pulse in cap systems, colon targeted drug delivery.