Abstract

THE FORMULATION OF ORODISPERSIBLE FILM OF CETIRIZINE BY CASTING METHOD

*Shaheed Shaikh, Suvasi Patel, Lisha Patel, Charmi Patel, Dr. Jitendra Patel and Dr. Umesh Upadhyay

Abstract

Thin-film drug conveyance utilizes a dissolving film or oral medication strip to control drugs employing absorption in the mouth (Buccal or sublingual) and additionally through the small digestion tracts (enteric). A film is readied utilizing hydrophilic polymers that quickly disintegrate on the tongue or Buccal fossa, conveying the medication to the fundamental diffusion through disintegration when contact with the fluid is made. Slight film drug conveyance has arisen as a high-level option in contrast to the customary tablets, containers, and fluids regularly connected with a solution and OTC prescriptions. Comparative in size, shape, and thickness to a postage stamp, meager film strips are regularly intended for oral organization, with the client putting the strip on or under the tongue (sublingual) or along within the cheek (Buccal). These medication conveyance alternatives permit the drug to sidestep the principal past digestion in this way making the medicine more bioavailable. As the strip breaks up, the medication can enter into the circulation system enteric, Buccal or sublingual. Assessing the fundamental trans membrane medication conveyance, the Buccal mucous membrane is the favored locale when contrasted with the sublingual mucosa. Solvent Casting method use to prepare films. Cetirizine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. It is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose. With the help of HPMC & PVA polymers the oral films formulated. Six batches were formulated with different types of concentration selected in it; and the films evaluated for weight variation, content uniformity, folding endurance, thickness, surface pH, tensile strength, % elongation, % moisture absorption, %moisture loss in vitro disintegration and in vitro dissolution. While the film made up of 300mg HPMC polymer released 93.6% of drug within 2 minute which was the best results among them.

Keywords: Oral Film, Sublingual Film, Cetirizine, HPMC, PVA, Solvent Casting, Buccal Film, Fast Dissolving Oral Film.