Abstract

FORMULATION AND EVALUATION OF MODEL DRUG LOADED FLOATING MICROSPHERES

Parita Patel*, Vrushti Patel, Donil Patel, Dr. Chainesh Shah and Dr. Umesh Upadhyay

Abstract

Microspheres are characteristically free flowing powders having particle size ranging from 1-1000 μm consisting of proteins or synthetic polymers. The point of present work is to get ready floatng microspheres of Abacavir sulphate utilizing HPMC K100M and HPMC K4M as polymer. There are various approaches in delivering therapeutic substance to target site in sustained controlled release fashion. Abacavir sulphate is an enemy of HIV drug. The short half existence of Abacavir sulphate and different organization portion make Abacavir sulphate an excellent contender for formulation of floating drug delivery system. It is reliable means to deliver drug to target site with specificity, if modified and to maintain desired concentration at site of interest. Moreover microspheres are of micron size so they can easily fit into various capillary beds which are also having micron size. Floating microspheres of Abacavir sulphate were set up by dissolvable dissipation technique utilizing HPMC K100M and HPMC K4M as polymer. There are various departments of medicine like cancer, pulmonary, cardiology, radiology, gynecology, and oncology etc., numerous drugs are used and they are delivered by various types of drug delivery system. Purpose of review is to compile various types of microspheres, different methods to preparation, its applications and also various parameters to evaluate their efficiency.

Keywords: Microspheres, Abacavir Sulphate, Floating drug delivery system, Polymer.