Abstract

A PROSPECTIVE COMPARITIVE STUDY OF HEALTH RELATED QUALITY OF LIFE OF TICAGRELOR AND CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROME – A PILOT STUDY

Aadarsh V.S.*, Jisna K. Philip, Shilpa S. Nair, Tasnim Nazeer, Dr. Subash Chandran M.P. and Dr. Karthika Lal B.

Abstract

Background: Acute coronary syndrome describes a range of conditions associated with sudden, reduced blood flow to the heart. Ticagrelor and Clopidogrel are common anti Platelet drugs used along with Aspirin in Dual anti-platelet therapy. Ticagrelor is a direct acting P2Y12 receptor antagonist whereas Clopidogrel is an anti-platelet drug in prodrug form. Methods: The study was carried out in 24 patients with ACS. The study was conducted by categorising them into two groups, 12 patients taking Ticagrelor and 12 patients taking Clopidogrel. Health related QOL of Ticagrelor and Clopidogrel was assessed using SF-36 questionnaire in patients with acute coronary syndrome. Result: By using SF-36 questionnaire, it was found that Ticagrelor and Clopidogrel showed almost similar effect in QOL of patients. A slight increase in the QOL was found in patients taking Ticagrelor. There was a significant improvement in QOL after patient counselling. Conclusion: It was concluded that, Ticagrelor is slightly more efficient than Clopidogrel. There is a significant improvement in the QOL scoring in patients taking Ticagrelor when compared to that of patients taking Clopidogrel. A significant improvement was found in the QOL of patients after patient counselling.

Keywords: Acute coronary syndrome, Ticagrelor, Clopidogrel, Quality of life.