DEVELOPMENT AND VALIDATION OF Q- ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD SIMULTANEOUS ESTIMATION OF SIMVASTATIN AND LABETALOL HCL IN COMBINED DOSAGE FROM
Mohite Popat, Wagh Jyoti, Mane Pradnesh* and Yelwande Sachin
Abstract
A simple, precise, accurate and economical methods without any
extraction step’ The solvent used was 0.25N sodium hydroxide. Two
wavelengths 246.00nm (λ max of Labetalol HCl) and 243.48nm
(Isoabsorptive point) were selected for estimation of Labetalol HCl and
Simvastatin for Q-absorbance ratio method. The concentrations of a
drugs were determined by a using ratio of Q absorbances at
isoabsorptive points and at the λ-max of Labetalol HCl methods was a
successfully applied to pharmaceuticals dosage froms.
Keywords: Labetalol HCl, Simvastatin, 0.25N sodium hydroxide.
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