Abstract

DEVELOPMENT AND VALIDATION OF Q- ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD SIMULTANEOUS ESTIMATION OF SIMVASTATIN AND LABETALOL HCL IN COMBINED DOSAGE FROM

Mohite Popat, Wagh Jyoti, Mane Pradnesh* and Yelwande Sachin

Abstract

A simple, precise, accurate and economical methods without any extraction step’ The solvent used was 0.25N sodium hydroxide. Two wavelengths 246.00nm (λ max of Labetalol HCl) and 243.48nm (Isoabsorptive point) were selected for estimation of Labetalol HCl and Simvastatin for Q-absorbance ratio method. The concentrations of a drugs were determined by a using ratio of Q absorbances at isoabsorptive points and at the λ-max of Labetalol HCl methods was a successfully applied to pharmaceuticals dosage froms.

Keywords: Labetalol HCl, Simvastatin, 0.25N sodium hydroxide.