Abstract

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRI TABLETS OF GLIBENCLAMIDE

*M. Shiroja, N. Rajitha and Pola Kranthi Kumar

Abstract

The aim of the present study was to fabricate and evaluate controlled release tablets glibenclamide, using different polymers like Guar gum, Xanthun gum HPMC K 100 and CMC which is suitable for delivering the drug for sufficient long time and reduce frequency of dose. Modified release drug delivery systems are designed by different techniques like enteric coating, osmotic pump, pro-drugs, transdermal patches and matrix tablets. Among the various techniques used, recently the attention of pharmaceutical researchers has been attracted by the matrix tablets because of their ease of manufacturing. Different types of polymers are used to control the release of drugs from the dosage forms for absorption by the human body. Though a variety of polymeric substances are available to serve as release retarding matrix Materials there is a continued need to develop new, safe and effective release retarding materials for matrix tablets.

Keywords: Glibenclamide, Guar gum, Xanthun gum HPMC K 100 and CMC.