FORMULATION DEVELOPMENT AND IN-VITRO EVELUATION OF BUCCAL TABLETS OF BENIDIPINE HCL TABLET
*N. Rajitha, 2M. Shiroja, V. Lokesh Babu and A. Srinivasa Rao
Abstract
The aim of the present study was formulation development and in-vitro
evaluation of benidipine hydrochloride tablet of strength 4 mg. Direct
compression technique was chosen to develop a finished
pharmaceutical product. Various formulations (F1-F8) were taken. In
these trials, drug: excipient ratio was varied and the effect of diluents,
and various polymers like, HPMC 15 cps as a rate controlling polymer,
and Sodium Alginate, Chitosan, Carbopol 940 are as mucoadhesive
polymers on the performance tablets was studied.All the formulation
has hausner’s ratio between the 1.10 to1.18. It indicates all the
formulation show better flow property. Among all formulation F7
showed in-vitro drug release 98.9% for 12hrs. And which is showed
better release than marketed preparation hence considered as most
promising preparation.
Keywords: Benidipine Hydrochloride tablet, HPMC 15 cps as a rate controlling polymer, and Sodium Alginate, Chitosan, Carbopol 940, mannitol, lactose, magnesium stearate, talc.
[Full Text Article]