Abstract

A STUDY ON THE PHARMACOTHERAPY OF PARA NASAL SINUSITIS IN A TERTIARY CARE HOSPITAL

Dr. Anand R Kalamdani*, Dr. Pavithra Krishnan, Dr. T M Nagraj,Dr. Basavaraj Bhandare

Abstract

Background: Episodes of Acute Rhinosinusitis are common among adults and are associated with a significant amount of morbidity. The symptoms of Rhinosinusitis are nasal drainage, congestion, and sinus pressure. As diagnosing bacterial sinusitis is difficult, the misuse and overuse of antibacterials for the treatment of sinusitis, has become a major problem throughout the world. Aims and Objectives: To analyse the Pharmacotherapy in Acute Bacterial Sinusitis and to assess the efficacy and tolerability of the Antimicrobials prescribed. Materials and Methods: A total of 60 patients diagnosed with Acute Bacterial Sinusitis were included in the study and their prescriptions were assessed which included Antimicrobials and adjuvant drugs used, route of administration, dose, tolerability, side effects and drug interactions were recorded. Results: Out of 60 patients who completed the study, 38% were males and 62% were females. Most common symptom that patients presented were nasal congestion (n=60), headache (n=50), post nasal drip (n=50). 90% of the study group received a Antimicrobial belonging to Beta Lactam group. NSAIDS like Paracetamol and Decongestants were used in all patients and Amoxicillin Claavulinic acid combination was the most frequent antimicrobial prescribed. The subjects showed good tolerability with minimal to no side effects. Conclusion: In our study we found that Amoxicillin Clavulinic acid was the primary option due to its proven efficacy, safety and tolerability. The other antimicrobials (majority Beta lactam group) that were prescribed also showed good tolerability and patient compliance.

Keywords: Paranasal Sinus Infections, Pharmacotherapy, Antimicrobials, Acute Bacterial Rhinosinusitis.