Abstract

FORMULATION AND EVALUATION OF MICROSPHERES FOR COLON TARGETING

Sagar Panse* and Anwar Iqbal Khan

Abstract

Irritable bowel disease is very common colon disease. Deflazacort is one of the best drugs with clinical activity against Irritable bowel disease. Microsphere system are effectively protect drugs against premature degradation, to localize drug molecules at the target site of action and to control the time and rate of release. Mucoadhesive microspheres enhance the bioavailability of orally given drugs by lengthened contact time of drug with the intestinal mucosa. The main disadvantage of these microspheres is adherence to the substrate by non-specific interaction. To overcome this limitation, microspheres are prepared by emlsification method to treat irritable bowel disease.

Keywords: Deflazacort, Colon targating, Microsphere, Mucoadhesive polymers, IBD.