Abstract

IN SILICO ANALYSIS OF THE INTERACTIONS OF METFORMIN VS. AMINO ACIDS USING QUANTUM CHEMISTRY

Hanna Samantha Varela Leyva*, Benigno Santiago Carrión Sesma and Manuel González Pérez

Abstract

This paper examines the oxidative-reducing molecular characteristics at the amino acid level and metformin (MTF). This drug is top of the line and is used to treat diabetes. This disease is one of the most suffered and with the highest death rate in the country. In current statistics, scientists rank diabetes as the second leading cause of death. The Electron Transfer Coefficient (ETC) was used as the primary calculation tool. This concept is defined as the dimensionless parameter, describing an electrochemical interaction; they are interpreted as the number of times the potential energy is needed for the electron to jump from a prohibited band from one molecule to another. MTF is an antioxidant drug for both AA and nucleic acids. None of the quantum interactions presented as an oxidizing agent that produces free radicals, being of vital importance for the stable replication of DNA and RNA and preventing the addition of inert elements that could structurally and functionally alter the cell.

Keywords: Experimentation in silico; Metformin; amino acids; quantum chemistry; electron transfer coefficient.