Abstract

A REVIEW ON: CARDIAC GLYCOSIDES AS ANTI-CANCER AGENT

Sk. Sultanul Arafin*, Md. Kabirul Islam Mollah and Retwik Manna

Abstract

cardiac glycosides are naturally occurring compounds. They are mainly known for their activity in treating congestive heart failure and cardiac arrhythmias. Recently, they are recognized as potential anticancer compounds. The primary target of cardiac glycosides as anticancer is Na+/K+-ATPase pump. Cardiac glycosides also activates the intracellular signaling pathways by which they mediate the apoptosis, autophagy, immunogenic responses. Most recently, it has been suggested that cardiac glycosides cause tumor-specific immune responses. This is a brief review of the anticancer aspects of CGs as new strategies for immunotherapy.

Keywords: Cardiac glycoside, Anti-cancer agents, Na+/K+-ATPase pump.