Abstract

EVALUATION OF THE ANTIULCER ACTIVITY AND GC-MS SPECTROSCOPIC ANALYSIS OF THE CRUDE ETHANOLIC EXTRACT OF PEURARIA PHASEOLOIDE LEAF (ROXB) BENTH. (FABACEAE)

Bruce S. O.*, Onyemailu V. O. and Orji C. E.

Abstract

The current study was carried out to evaluate the antiulcer activity using pylorus-ligation induced model and a GC-MS analysis of the ethanolic leave extract of Peuraria phaseoloides plant. Gastric protection was evaluated by assessing different parameters like gastric volume, pH, ulcer index and percentage inhibition of ulceration. Omeprazole was used as the standard at a dose of 20mg/kg while those of the extracts were 50mg/kg, 150mg/kg and 300mg/kg. The extract showed better activity when compared to the negative control. Significant reduction in ulcer index (measures of ulcerated area) was noted for 50mg/kg (P

Keywords: Peuraria phaseoloides, pylorus ligation, GC-MS, antiulcer.