Abstract

LULICONAZOLE EMULGEL: CHARACTERIZATION, PREPARATION, AND EVALUATION

Varfa Pragya* and Dr. Agrawal Shikha

Abstract

The objective of this work is to develop emulgel of Luliconazole which will increase skin penetration of drug in comparison with present marketed preparations of the drug. The Luliconazole has antifungal activity. It acts by inhibiting lanosterol demethylase, which is major component of fungus cell wall. It was concluded that Luliconazole emulgel formulation based on solubility studies Oleic acid as oil, Tween 80, and Span 80 as emulsifiers and propylene glycol and cetostearyl alcohol as co-surfactant were selected for preparation of emulgel. The emulgels were prepared using different combinations of oil, emulsifiers, co-surfactant and carbomer (Carbapol 940). The prepared emulgel were also evaluated for their physical properties, pH, Rheological study, drug content determination and in-vitro drug release. In-vitro release study demonstrated diffusion controlled release of luliconazole from formulation up to 8 hours. The drug release profile exhibited zero order kinetics.

Keywords: Topical drug delivery, Emulgel, Luliconazole.