Abstract

BIOEFFICACY OF NYCTANTHES ARBOR TRISTIS LINN., ON CCL4 INDUCED HEPATOTOXICITY IN SWISS ALBINO RATS

V. Bharathi, J. Jayachitra and *P. Venkatalakshmi

Abstract

The present study has been carried out to evaluate the bioefficacy of Nyctanthes arbor tristis leaves on CCl4 induced hepatotoxicity in swiss albino rats. Preliminary phytochemical analysis revealed the presence of tannins, saponins, alkaloids, flavanoids, steroids, phenolic compounds, reducing sugars and carbohydrates. Elevation of LDH, GGT and decline in NADH-dehydrogenase, Glucose-6-phosphatase, Na+/K+ dependent ATPase, Total ATPase was noted in CCl4 administred rats. Total reversal of all the above said parameters was noted in both ethanolic extract treated and Silymarin treated rats. The efficacy of the plant drug has been found to be more than the standard drug Silymarin.

Keywords: Biochemical analysis, HPLC, Nyctanthes arbor tristis, Phytochemical screening.