Abstract

TRANSFEROSOMES: EMERGING DELIVERY SYSTEM FOR ENHANCING DRUG PERMEATION THROUGH SKIN

Kamini Kashyap*

Abstract

The use of vesicular carriers has lately emerged as a viable technique for reducing the stratum corneum's obstructive effects. Transferosomes, also known as ultradeformable lipids and elastic liposomes, have sparked a lot of interest in cutaneous delivery. They are primarily used to treat a variety of chronic skin conditions, and they are also useful for focused and controlled distribution to ensure patient compliance. These self-assembled nanocarriers are capable of adapting themselves to the stratum corneum's pore size. Edge activators (specific surfactants), phospholipids, buffering agents, and other substances may be found in transferosomes. The impact of edge activators and their concentration gives constructed vesicles the desired flexibility. Elastic liposomes have the capacity to optimize drug solubilization, effective drug loading capabilities, and therapeutic molecule permeability. As nanocarriers, transferosomes have enhanced reflectivity and provide a flexible foundation for effective transdermal applications. These one-of-a-kind nanocarriers also have exceptional elasticity and penetration. These systems are thought to be safe, with effective delivery mechanisms for pharmaceutically and cosmetically active chemical moieties. Recent scientific findings demonstrating the necessity of ultradeformable liposomes have shown consistent and effective drug penetration. This publication includes up-to-date research as well as comprehensive updates on critical difficulties and the use of future transferosomes with improved bioavailability profiles.

Keywords: Transferosomes, Transdermal delivery, Bioavailability, Self-assembled, Skin permeation, Ultradeformable vesicles.