Abstract

LIPID PEROXIDATIVE DAMAGE AND ALTERATIONS IN ANTIOXIDANT STATUS IN RAT ERYTHROCYTES ON REPEATED EXPOSURE OF ?-CYHALOTHRIN AND FLUORIDE ALONE AND IN COMBINATION

Imtiyaz Ahmad, Rajinder Raina*, Pawan Kumar Verma, Mahrukh Ahmad, M Sultana

Abstract

Accidental exposure or injudicious application of pesticides and toxic metals cause adverse health consequence in non-target species including human and animals. The present study was aimed to investigate the lipid peroxidative damage and alterations in antioxidant status in rat erythrocytes on repeated exposure of λ-cyhalothrin (LCT) and fluoride (F) alone and in combination. Forty two wistar were divided into seven groups with six rats in each. Group I without treatment served as control. Group II and III were provided drinking water containing F at the rate of 1 and 10 ppm, whereas rats of Group IV and V were administered LCT at the dose rate of 2 and 10 mg/kg through oral gavage respectively. The animals of group VI and VII received both toxicants daily for 28 days. Repeated exposure of either LCT or F produced significant (p

Keywords: ?-cyhalothrin; Fluoride; Antioxidant parameters; Free radicals.