Abstract

ADVANCED DRUG DELIVERY FROM NOSE TO BRAIN: AN OVERVIEW

Sagar Kishor Savale*

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Abstract

In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system (CNS), in particular, the brain. Delivery of drugs to the brain is a most formidable challenge in current scenario due to presence of physiological barriers that restricts the delivery of drugs to CNS. Thus, since last few decades, nasal route has attracted a wide attention of researchers as a convenient, non-invasive, reliable, and safe route to achieve faster and higher levels of drug in the brain. It is thought to do so through olfactory route of drug transport which bypass the blood-brain barrier (BBB) and allow the direct transport of drug from the nose to the brain. Nose to brain drug delivery techniques and devices of brain drug transport that have been feasible in treating various brain disorders. This review sets out to discuss some Drug Transport Pathways, Factors Influencing Nasal Drug Absorption, Formulation Strategies Nose to Brain, Colloidal Carriers in Nose to Brain Drug Delivery Systems, Nasal Delivery Devices and patents on Nose to Brain drug delivery systems and Marketed product under nasal drug delivery system.

Keywords: Nose to Brain, Blood-Brain barrier, brain targeting, Nasal drug delivery, delivery pathways and devices.