Abstract

FORMULATION AND EVALUATION OF FLOATING PELLETS OF AMOXICILLIN TRIHYDRATE FOR ERADICATION OF H.PYLORI

Rakesh Jatav*, Digvijay Singh, Priyanka Rathore, Nishi Prakash Jain and R. B. Goswami

.

Abstract

Oral ingestion is the most convenient and commonly used method of drug delivery. A major constraint in oral controlled release drug delivery (CRDD) is that not all drug candidates are absorbed uniformly throughout the gastrointestinal tract. The aim of this research work to develop floating pellets of Amoxicillin Trihydrate which remain in stomach for longer duration to eradicate the H.Pylori. Most important reason for failure of anti H.pylori therapy is inability of the delivery systems in maintaining effective antimicrobial concentration for longer duration in stomach. Increasing failures in current anti H. pylori therapy is driving research towards exploring alternative therapeutic moieties and novel drug delivery strategies. Floating Pellets were prepared by combining the Microcrystalline cellulose and other polymers the drug release rate increased due to a formation of a porous on the pellets. Formulation F-3 (containing Microcrystalline cellulose 5% w/w and hydroxypropyl methyl cellulose 9%w/w) showed better release profile i.e. very low initial drug release in the first two hrs and afterwards the rate of drug release increased with almost complete release of the drug being achieved in 97.03% at 24 hrs respectively. Hence F-3 release profile was passed all USP test-1 limits. Pellets technique using Microcrystalline cellulose as the retardant has successfully extended the release of Amoxicillin Trihydrate from its pellets formulations. One month stability studies of formulated were stable, It is observed that no variation occurs in case of dissolution profile and drug content when it is stored in 40°C / 75% RH stability chamber.

Keywords: Pellets, Gastroretentive drug delivery system, Amoxicillin Trihydrate, H.Pylori.