Abstract

FORMULATION AND ESTIMATION OF ATOMOXETINE HYDROCHLORIDE BUCCAL DRUG DELIVERY SYSTEM

Pragya Srivastava* and Hema Jaiswal

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Abstract

As oral route is the preferred route of administration of majority of drugs but it has certain limitations such as presystemic metabolism or first pass metabolism in liver, g.i.t upset and destructions of enzymes. After gone through extensive review of literature, this research focuses on designing, development and estimation of atomoxetine hydrochloride buccal drug delivery system with different and suitable vehicles and plasticizers with different ratio of mixing and evaluation of same by following standard parameters. The buccal patch was formulated by most conventional method- solvent casting and evaluated for multiples of parameters such as surface pH, folding endurance, flatness, moisture content, uniformity of contents, weight variations, in-vitro drug release and stability. In results, the formulated buccal patch demonstrated a significant buccal patch by following excellent form of patches characteristics. They all have seen of great purity because of strength of polymers used. In conclusion, it may beneficial by the use in the market. It shows a significantly low investment of money. In future aspects, it may be applied for the treatment of various neurological and other aspects of diseases.

Keywords: Atomoxetine hydrochloride, Buccal delivery system, ADHD, Conventional.