Abstract

ANTIFUNGAL ACTIVITY OF BURSERA PENCILLATA LEAF EXTRACT ON DERMATOPHYTES

Ashok. T*, Madhuri. N, Sravanthi.P, Shilpa Vemula

Abstract

To evaluate the in vitro antifungal activity of Bursera penci l lata leaf extracts and fractions on the clinical isolates of dermatophytic fungi like Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis, Microsporum gypseum and Epidermophyton floccosum. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of various extracts and fractions of the leaves of Bursera penci l lata were measured using method of National Committee for Clinical Laboratory Standards (NCCLS). Bursera penci l lata leaf extracts and fractions were found to have fungicidal activity against various clinical isolates of dermatophytic fungi. The MIC and MFC was found to be high in water and ethyl alcohol extracts and methanol fractions (200 g/mL) against dermatophytic fungi studied. Bursera penci l lata leaf extracts significantly inhibits the growth of all dermatophytic fungi studied. If this activity is confirmed by in vivo studies and if the compound is isolated and identified, it could be a remedy for dermatophytosis

Keywords: Bursera penicillata, Antimicrobial activity, Minimum inhibitory concentration (MIC) and Minimum fungicidal concentration (MFC).