Abstract

INTRANASAL MUCOADHESIVE DRUG DELIVERY FOR PARKINSONISM WITH CENTELLA ASIATICA

Anju K.* and Shammika P.

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Abstract

Parkinson’s disease (PD) is an important age-related neurodegenerative disorder. Resulting from the loss of dopamineproducing neurons in the substantia nigra pars compacta of midbrain, characterized by motor and non- motor symptoms. Nowadays, 80% of people use medicine which is directly or indirectly derived from plants. There are many traditional plants responsible for neuroprotective property. This review focus on Centella asiatica, could offer a useful support to the Parkinsonism therapy by acting as a neuroprotective antioxidant and thus prevent the neuronal damage in brain regions associated with Parkinsonism. The Asiaticoside, present within the Centella asiatica extract are simpler in neuro protecting activity from oxidative stress. Therapy through intranasal administration has been an accepted sort of treatment within the Ayurvedic system of Indian Medicine. Intranasal (IN) drug delivery used for treating various CNS diseases like Alzheimer’s, Schizophrenia, Meningitis, and Parkinson’s diseases. IN delivery also offers the advantage of straight forward administration, cost effectiveness and convenient. But in some cases low duration thank to mucocilliary clearance may be a major challenge in nasal drug delivery. The utilization of mucoadhesive can resolve this problem by localizing the formulation during a particular region of the nasal cavity, thereby improving the bioavailability of medicine. Meaning that mucoadhesive based drug delivery will be better in combination with intranasal route.

Keywords: Parkinsonism, Centella asiatica, Intranasal delivery, Mucoadhesive based drug delivery.