Abstract

A COMPREHENSIVE REVIEW ON EXTENDED RELEASE TABLETS WITH ASHWAGANDHA AND VELVET BEAN FOR DEPRESSION

Murshida K. M.* and Shammika P.

.

Abstract

Depression is a psychological disorder that is characterized by depressed mood or loss of interest in activities, causing significant impairment in daily life. More than millions of people suffer from depression in all ages. There are different types of antidepressant drugs used to treat depression. About 80 % of world population trust on traditional herbal medicine for the primary health care. Now a days, herbal remedies are considered as dietary supplement for disease prevention as well as alternative medicine. In the world a wide varities of herbal medicine are available in the market. There are many herbal plants which are responsible for antistress activity. The study mainly focus on the combination effect of Withania somnifera and Mucuna pruriens for antidepressant activity. Based on literature review, The sitoindosides VII-X and Withaferin-A present in the Ashwagandha showing Antistress activity, have been shown to have significant anti-stress activity against acute models of experimental stress and also levodopa which is present in the velvet bean showing Antistress, neuroprotective as well as Antioxidant properties. The extended release dosageforms are important tool in medicinal practice and also offers a wide range of advantages to the patients. It is the most preferred route because of ease of administration. Extended release dosage form are those which release drug slowly, so that the plasma concentrations are maintained at a therapeutic level for a prolong period of time usually between 8-12hrs. It allows a reduction in dosing frequency and provide long action of the drug.

Keywords: Depression, Withania somnifera, Mucuna pruriens, Extended release tablets.