Abstract

CERIMETRIC DETERMINATION OF PROMETHAZINE BULK DRUG FORM AND IN TABLETS

*Mallapu E. Rani

Head of Dept. of Chemistry, Rayalseema University, Kurnool, Andhra Pradesh, India.

Abstract

We present the validation of a developed a new spectrophotometric method based on a charge transfer complexation reaction of heterocyclic ring containing drug. In this method, the oxidation of chlorapromazine drug. In this method, the oxidation of Promethazine drug by a known excess amount of cerium IV sulphate in acid medium, the unreacted cerium IV sulphate is treated with Iron II Sulphate, After 5 minutes the resultant Iron III Sulphate solution was treated with (1M) Ammonium thiocyanate, immediately it forms blood red colour of Iron III Sulphate – thiocyanate drug complex. This blood red coloured complex formed under standardized conditions was measured at 480 mm, Beer’s law was obeyed for 10-40 µg / ml-2 of Promethazine. Results of analysis were validated statistically and by recovery studies. The procedures described were successfully applied to the determination of Promethazine bulk drug form and in tablets.

Keywords: Promethazine spectrometric cerium IV sulphate, Iron III Sulphate (ammonium ferrous sulphate solution) Ammonium thiocyanate solution.