Abstract

AN OVERVIEW OF ANALYTICALMETHODS FOR DETERMINING METFORMIN HYDROCHLORIDE AND PIOGLITAZONE HYDROCHLRIDE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Pragati Sorate*, Ashwini Thorat, Shrutika Jagtap, Ashwini Taware and Rajendra Bandal

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Abstract

Diabetes mellitus is one of the world’s major disease and is the third leading cause of death in the United States after heart disease and cancer. In the India, about 2-6% population suffer from diabetes or related complications. Anti-diabetic drugs treat diabetes mellitus by lowering glucose level in the blood. Mostly anti-diabetic drugs are administered orally except the insulin, exenatide and pramlintide. There are different types of anti-diabetic drugs, and there selection depends on the nature of diabetes, age and situation of the person and many other factors. Treatments include the agents which include the agents which increase the amount of insulin secreted by the pancrease, or increases the sensitivity of target organs to insulin, and agents which decrease the rate at which glucose is absorbed from the gastrointestinal tract. People are mainly focused on insulin, insulin analogues, oral hypoglycemic agents and various other complementary and alternate medicines to control the blood glucose levels in diabetes. The present review summarizes in brief about the drugs used for treatment of diabetes mellitus.

Keywords: Diabetes Mellitus, Glucose, Anti-diabetic Drugs, PPAR, Insulin.