Abstract

PHARMACOLOGICAL EVALUTION OF ANTI-ULCER ACTIVITIS OF BAUHINIA FORFICATA LEAVES EXRACTS

Abhinav Kumar Chauhan*, B. M. Vrushabendra Swamy and M. Rupesh Kumar

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Abstract

Gastric ulcer is taking place in day today life due to excess use Steroids, NSAIDs, in stress, alcohol intake. For the treatment of gastric ulcer disease and peptic ulcer disease may chemical drugs are available in market such as Proton pump inhibitors, H2 Antihistaminic Drugs Anticholinergics The most serious side effect of proton pump inhibitors are Bacterial infections, Anaemia, Bone fractures, Damage to arteries, Dementia, Heart attack or heart failure, kidney disease or injuries, Premature death, Stroke. The serious side effects H2 blocker are Mental Confusion, Headache, leucopoenia, thrombocytopaenia, acute pancreatitis, heart palpitations, galactorrhoea, gynecomastia, difficulty in breathing. From last 2-decade people of world are move towards the herbal medicine because it will produce is very less toxic effect when we compare to chemical drugs. The Phytochemical Tests shown Alkaloids, Carbohydrate, Glycosides, Phytosterols/Terpens Oils Protein, Tannins and Saponins. The TLC studies displayed the presence of compound such as, Flavonoid, Terpenoids and alkaloid with the significant Rf values. The pre-clinical pharmacological anti-ulcer impacts had seen by applying numerous extracts of Bauhinia forficata such as aqueous, chloroform and methanol on different gastric-ulcer models, are pylorus ligation, Stress induced, Aspirin induced, and Ethanol induce ulcers models. These test sample had administered thru oral route at a dose of 400mg/kg. Entirely extracts improved the ulcer healing of all gastric ulcers models (P< 0.05). But methanol extract had more significant when we equate with standard drug ranitidine (P< 0.001). In the pylorus ligation, stress induce ulcer, ethanol induces ulcer and aspirin induce ulcer showed remarkable anti-ulcer activities (P< 0.05). From this experiment and biochemical test result methanolic leaves extract of Bauhinia forficata had shown more significant ulcer healing activity.

Keywords: Bauhinia forficata, Ulcer index, anti-ulcer models, TLC and histopathology.