Abstract

ANTIULCER EFFECTS OF POLYHERBAL FORMULATION OF LAWSONIA INERMIS AND AZADIRACHTA INDICA

*Sonam Rajwar, Mr. Pankaj Khatri

Department of Pharmacognosy, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur-302025, Rajasthan, India.

Abstract

This Study was planned to investigate the different concentrate gradient formulation of Lawsonia inermis and Azadirachta indica in Naproxen & Histamine induced model. In Naproxen induced model the test formulation of Azadirachta indica & Lawsonia inermis (F1) was significant and reduced the ulcer area to 2.4±0.12 mm2 which is very near to standard . The test drug in F2 potency also significantly reduced the total ulcer area upto 3.58±0.11 mm2. The test formulation was found insignificant in F3 and F4. But Formulation F5 had extraverted the ulcer area upto an great extent to 30.41±0.21 mm2 and is completely insignificant. In Histamine induced ulcer model states that the total ulcerative area in control (no drug ) group was 10.65±0.06 mm2 whereas in standard (Ranitidine) group it significantly reduced to 2.71±0.12 mm2. The test formulation of Azadirachta indica & Lawsonia inermis F1, F2 and F3 were significant and reduced the ulcer area to 8.1±0.12mm2 and 8.86±0.13 mm2 . Whearas F4 was non significant. But F5 had extraverted the ulcer area upto an great extent to 63.56±0.24 mm2 and is completely insignificant.

Keywords: Ulcer, Lawsonia inermis, Azadirachta indica, Naproxen, Histamine.