Abstract

ON GOING RESEARCH FOR COVID-19 VACCINES- A REVIEW

Sahil B. Shaikh*, Shubham R. Shinde and Shubham B. Sabale

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Abstract

Novel corona virus is an infectious disease which mainly caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first infected in December 2019 in Wuhan, China, and has since expanded globally, resulting in an ongoing epidemic in all over world. In 11 May 2020, more than 4.16 million cases have been arrive across 187 countries and territories, resulting in more than 3,50,000 deaths. More than 2.0 million people have recovered. common symptoms like fever cough, fatigue, loss of appetite, shortness of breath, sputum production, and muscle and joint pains. While sever cases show acute respiratory distress syndrome, many organ failure, septic shock, and blood clots. The main diagnosis method is by real-time reverse transcription polymerase chain reaction (rRT-PCR) from nasopharyngeal swab. Nowadays, the outbreak is still spreading and there is different type of study had been conducting to prevent the infection. Lots of organizations began work on produce vaccines for 2019 n-CoV based on the published genome. Novel network-based integrative methodology also used for rapid antiviral drug repurposing against SARS-CoV-2 Virus. This method combines a system pharmacology- based networks drug platform in which quantifies the interaction between host-virus interacted and drug targets in the human Protein-Protein Interactions network.

Keywords: SARS-CoV-2, rRT-PCR, vaccine development, animal model, clinical trials.