Abstract

QUANTITATIVE ESTIMATION AND PHARMACOLOGICAL STUDIES OF ABRUS PRECATORIUS LINN. ROOT EXTRACT

Ashaolu Victoria Oladimeji* and M. F. Valan

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Abstract

The study of plant-medicine and Phyto-compounds is the ultimate need for the hour. Since synthetic drugs have prevailed over time inflicting side effects worse than the purpose it is used for as medicine, this study gives a clue and create global awareness of Abrus Precatorius Linn, a substitute to Glycyrrhizin glabra, an important medicinal herb to be therapeutic and could be the cure to human numerous diseases such as COVID-19. The quantitative estimation of Phyto-compounds suggests the presence of tannin, phenol, steroid, flavonoid, alkaloid, and carbohydrates. These compounds are responsible for the various pharmacological activities such as antioxidant activity using DPPH, FRAP and Reducing power activity, antibacterial activity, antidiabetic activity, and anti-inflammatory properties. In all, methanol extract proved to be the leading potent potential drug extract due to the strong occurrence of polyphenolic compounds such as flavonoids, tannins, steroids, and phenols. It also demonstrated significant antibacterial activity against virulent strains. The extract fraction serves as a free radical inhibitor or scavenger or acting possibly as primary oxidant and inhibited the heat-induced albumin denaturation also serving as a starch-blocker. Hereby, possess to be a promising source of novel drug formulation after purification and characterization for the treatment of various ailments.

Keywords: Abrus Precatorius, COVID-19, Phyto-compounds, pharmacological activity, ailments.