Abstract

EFFECTS OF ORAL ADMINISTRATION OF AQUEOUS EXTRACT CAESALPINIA BENTHAMIANA ROOTS (FABACEAE) ON HAEMATOLOGICAL PARAMETERS IN MALE WISTAR RATS

Narcisse Boua Gnangoran*, Dumas Mayéré Glouanou and Paul Angoué Yapo

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Abstract

Caesalpinia benthamiana (Cb) is an African tropical, particulary in Côte d’Ivoire, plant whose roots are used in traditional medicine as an aqueous decoction for many purposes, especially for erection impairment. The current study performed to evaluate the effects of aqueous roots extract of C. benthamiana (AECb) on haematological parameters of male Wistar rats. Twenty (20) male rats weighing between 177-186g were used for the study. The rats were divided into four groups of five each based on body weight. Group I served as the control. Groups II, III and IV were administered varying doses (25, 50 and 100 mg/kg bw respectively) of AECb. The administration was done daily for 14 days. The results showed that only AECb at 100 mg/kg bw (High dose) induced a decrease erythrocytes, haemogobin, haematocrit and thrombocytes counts compared to control group. Aqueous roots extract of C. benthamiana at doses of 25 and 50 mg/kg bw are nontoxic on haematological parameters studied when administered orally to 14 days in male rats.

Keywords: Caesalpinia benthamiana roots; male Wistar rat; haematological parameters; nontoxic.