Abstract

HYPOLIPIDAEMIC AND HEPATOPROTECTIVE ACTIVITY OF GYNURA NEPALENSIS DC FLOWER EXTRACT IN STREPTOZOTOCIN INDUCED DIABETIC MICE

*Vijay Nigam¹, Dr. Padmaa M. Paarekh², Sukhwant Singh¹, Gaurav Goyanar¹, Neeraj Upmanyu³ & Jitendra Banweer¹

¹Sagar Institute of Research, Technology & Science- Pharmacy (SIRTS-P), Bhopal, 482048, M.P., India
²The Oxford College of Pharmacy, Bangalore, Karnataka, India.
³RKDF College of Pharmacy, Bhopal, MP, India.

Abstract

Objectives: In this study, the hypolipidaemic and hepatoprotective effect of aqueous extract of Gynura nepalensis DC was investigated in streptozotocin induced diabetic mice. Method: The flower extract of Gynura nepalensis DC in doses 100 and 200 mg/kg b.w was administered for 21 days and Triglyceride, Cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline Phosthatase (ALP). Results: Administration of the flower extract of Gynura nepalensis DC (100 and 200 mg/kg) for 21 days resulted in significant reduction in serum cholesterol (P

Keywords: Diabetes mellitus, Lipoproteins, Hepatic enzyme, Hypolipidaemic effect, Hepatoprotective effect, Gynura nepalensis