Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL EVALUATION OF SAPTAVIMSHATI GUGGULU IN THE MANAGEMENT OF ADENOMYOSIS

Sheela Pant*, Dr. L. P. Dei, Harisha C. R. and Vinay J Shukla

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Abstract

Background: Saptavimshati Guggulu is indicated in cough, asthma, inflammation, hemorrhoids, fistula, angina, flank pain, abdominal colic, proctalgia, nephrolithiasis, dysuria, infection, chronic fever, emaciation, abdominal distention, mental disturbance, skin diseases, all types of sinus wound, Dushta vrana, diabetes and filariasis. Considering adenomyosis as an inflammatory state as there is myohyperplasia surrounding the ectopic endometrial glands and stroma in myometrium, leading to bulky uterus, Saptavimshati Guggulu along with other therapy has been used to cure this disease. It can also be related to Dushta vrana as there is bleeding from the endometrial cells in the ectopic sites and adenomyosis is related to tissue injury and healing. Saptavimshati Guggulu has both anti-inflammatory and wound healing properties as it is indicated in Sotha (inflammation) and Dusta vrana, it has been used to treat adenomyosis. So for assurance of quality of herbal compounds, pharmacognostical and pharmaceutical analysis of the drug should be done. Methods: Saptavimshati Guggulu was subjected to microscopic evaluation for pharmacognostical, physiochemical analysis like weight variation, loss on drying, ash value, pH value, water soluble extract, alcohol soluble extract and highperformance thin layer chromatography (HPTLC). Results: Pharmacognostical study showed the presence of certain identifying characters of the ingredients of Saptavimshati Guggulu i.e., Triphala, Trikatu, Giloya, Musta, Chitraka, Kachur, Ela, Vidanga, etc. In pharmaceutical study, preliminary physiochemical analysis showed mean weight .469gm, pH value 5(by pH meter at room temperature), ash value 9.5% w/w, loss on drying 12.3%w/w, water soluble extract 59.3%w/w, alcohol soluble extract 25.4%w/w and HPTLC showed 6 spots in 254 nm and 4 spots in 366 nm. Conclusions: Pharmacognostical and physico-chemical observations revealed the specific characters of all active constituents of Saptavimshati Guggulu and confirmed the purity and genuinity of the drug.

Keywords: Adenomyosis, Pharmaceutical analysis, Pharmacognosy, Saptavimshati Guggulu.